Table of contents:
Ongoing and Upcoming Studies
Estimated Start: 2026 Q1:
Study Title:
Pilot Evaluation of tcVNS for Post-Exercise Recovery: Effects on Heart Rate Variability and Recovery-Related Biomarkers in Trained Athletes
Focus area:
Recovery / HRV
Design/study type:
Pilot
Institution / Country:
Lithuanian Sports University (LT)
Estimated Start: 2026 Q4:
Study Title:
Randomized, Double-Blind, Sham-Controlled Trial of tcVNS on Systemic Inflammation and Autonomic Function: Effects on CRP, IL-6, and HRV
Focus area:
Inflammation
Design/study type:
Randomized, double-blind (pilot RCT)
Institution / Country:
Autonomous University of Sinaloa (MX)
Estimated Start: 2026 Q1:
Study Title:
A Randomized, Sham-Controlled Trial of tcVNS for Insomnia Symptoms: Effects on Sleep Quality (PSQI) and Autonomic Regulation
Focus area:
Sleep
Design/study type:
RCT
Institution / Country:
Kaunas Clinics, LSMU Hospital (LT)
Estimated Start: 2026 Q1:
Study Title:
Feasibility Study of tcVNS for Chronic Cough Using Continuous Digital Cough Monitoring (Hyfe): Symptom Burden and Cough Frequency Outcomes
Focus area:
Nervous system / cough
Design/study type:
Pilot
Institution / Country:
Santaros Clinics, VUH (LT)
Estimated Start: 2026 Q1:
Study Title:
Randomized, Sham-Controlled Trial of tcVNS in Chronic Insomnia: Sleep Outcomes with Integrated HRV-Based Autonomic Endpoints
Focus area:
Sleep
Design/study type:
RCT
Institution / Country:
Vilnius Republican University Hospital (LT)
Estimated Start: 2026 Q1:
Study Title:
Feasibility Study of Peri-operative tcVNS After Cesarean Delivery: Postpartum Bleeding and Autonomic Tone Outcomes
Focus area:
FemHealth / Pain
Design/study type:
Pilot
Institution / Country:
Lithuanian University of Health Sciences (LT)
Estimated Start: 2026 Q1:
Study Title:
Exploratory Pre-Pilot Study of tcVNS and Biological Aging-Related Biomarkers: Inflammatory Markers and Glycan-Based Age Indices
Focus area:
Inflammation / longevity
Design/study type:
Prepilot
Institution / Country:
GlycanAge (UK)
Estimated Start: 2026 Q4:
Study Title:
Decentralized, App-Based Randomized Trial of tcVNS for Migraine: Effects on Attack Frequency and Pain Intensity
Focus area:
Pain / migraine
Design/study type:
RCT
Institution / Country:
Australia (The George Institute For Global Health)
Estimated Start: 2026 Q1:
Study Title:
Randomized, Sham-Controlled Adjunctive Trial of tcVNS in Migraine Management: Attack Frequency and Patient-Reported Outcomes
Focus area:
Pain / migraine
Design/study type:
RCT
Institution / Country:
Santaros Clinics, VUH (LT)
Estimated Start: 2026 Q2:
Study Title:
Randomized, Sham-Controlled Trial of tcVNS in Hypertension: Ambulatory Blood Pressure and Autonomic Function Endpoints
Focus area:
Heart / BP
Design/study type:
RCT
Institution / Country:
Santaros Clinics, VUH (LT)
Estimated Start: 2026 Q2:
Study Title:
Randomized, Sham-Controlled Trial of tcVNS for Chronic Subjective Tinnitus: Symptom Severity and Quality-of-Life Outcomes
Focus area:
ENT / nervous system
Design/study type:
RCT
Institution / Country:
Santaros Clinics, VUH (LT)
Estimated Start: 2026 Q2:
Study Title:
A Feasibility Study of Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) as Adjunctive Therapy for Temporomandibular Disorder Pain: Safety, Tolerability, and Signal-Finding Efficacy Outcomes
Focus area:
Pain
Design/study type:
pilot
Institution / Country:
Germany (site TBD)
Estimated Start: 2026 Q2:
Study Title:
Home-Use Dose-Finding Pilot Comparing Auricular VNS, Cervical tcVNS, and tDCS in Multiple Sclerosis: Feasibility and Symptom-Targeted Outcomes
Focus area:
MS/neuroimmunology
Design/study type:
Open-label comparative pilot
Institution / Country:
USA (NYU / partner discussed)
Ongoing Study:
Study Title:
HARMONY Trial: Randomized, Single-Blind, Sham-Controlled Crossover Study of Optimized tcVNS on HRV and Autonomic Regulation in Healthy Adults
Focus area:
Heart/BP/autonomic
Design/study type:
Randomized, single-blind, sham-controlled crossover pilot
Institution / Country:
ERASMUS MC
Ongoing Study:
Study Title:
Safety and Feasibility of tcVNS in Severe Traumatic Brain Injury in the Intensive Care Unit: An ICU-Based Pilot Study
Focus area:
ICU neurology/safety
Design/study type:
Pilot
Institution / Country:
HBDF, Brazil
Ongoing Study:
Study Title:
A Four-Week Exploratory Pre-Pilot Study of Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in Post-Acute Sequelae of SARS-CoV-2 (PASC): Changes in Patient-Reported Fatigue, Sleep, and Mood Outc
Focus area:
Fatigue/sleep/stress
Design/study type:
Prepilot
Institution / Country:
Private clinic (TBD)
Ongoing Study:
Study Title:
Effects of Non-Invasive Vagus NerveStimulation on Glycemic Variability inHealthy Adults Using Continuous GlucoseMonitoring and Wearable Biometrics
Focus area:
Metabolism
Design/study type:
IRB remote study
Institution / Country:
Remote / site TBD
Ongoing Study:
Study Title:
Evaluation of the Effectiveness of the Pulsetto Device for Non- Invasive Vagus Nerve Stimulation in Improving Health Outcomes
Focus area:
General health
Design/study type:
IRB remote study
Institution / Country:
Remote / site TBD
Table of contents:
Read more:
The effect of transcutaneous cervicalvagus nerve stimulation on the cardiacautonomic nervous system
Read StudyEvaluating the Efficacy of Bilateral Non-Invasive Vagus Nerve Stimulation in Reducing Migraine Symptoms: A Prospective Observational Study
Read StudyHave questions?
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